# GHK-Cu reading list

> The Good Peptide reading list — The Good Peptide reading list gathers the GHK-Cu collagen, topical-delivery, hair and gene-expression studies discussed in the essays.

A small collection with several different experimental settings: cultured cells, skin outside the body, a human combination trial and gene-expression analysis.

## Collagen and remodeling

Start with [the human fibroblast collagen experiment](https://pubmed.ncbi.nlm.nih.gov/3169264/). Then turn to [the tissue-remodeling review](https://pubmed.ncbi.nlm.nih.gov/18644225/) and [the skin-regeneration review](https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/). For me, the wider repair argument becomes much more absorbing after this particular synthesis result.

## Topical delivery

The [skin-layer penetration experiment](https://pmc.ncbi.nlm.nih.gov/articles/PMC3016279/) measures copper transport and retention in human skin outside the body. The [topical GHK review](https://pmc.ncbi.nlm.nih.gov/articles/PMC11830136/) brings the permeability problem into the discussion of skin outcomes.

## Hair and gene activity

The [human hair trial](https://pmc.ncbi.nlm.nih.gov/articles/PMC4969472/) concerns GHK in a combination with 5-aminolevulinic acid. The [isolated-follicle study](https://pubmed.ncbi.nlm.nih.gov/17703734/) concerns AHK-Cu. I’d resist merging those materials even in a hurried account.

The [gene-data review](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/) is the starting point for the expression signature and the threshold discussion. Its breadth is part of its fascination; the [gene-data essay](/gene-data) follows the questions that temper my enthusiasm.

## References

[1] Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ https://pubmed.ncbi.nlm.nih.gov/3169264/
[2] The human tri-peptide GHK and tissue remodeling https://pubmed.ncbi.nlm.nih.gov/18644225/
[3] GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/
[4] Human skin penetration of a copper tripeptide in vitro as a function of skin layer https://pmc.ncbi.nlm.nih.gov/articles/PMC3016279/
[5] Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective https://pmc.ncbi.nlm.nih.gov/articles/PMC11830136/
[6] Efficacy of a Complex of 5-Aminolevulinic Acid and Glycyl-Histidyl-Lysine Peptide on Hair Growth https://pmc.ncbi.nlm.nih.gov/articles/PMC4969472/
[7] The effect of tripeptide-copper complex on human hair growth in vitro https://pubmed.ncbi.nlm.nih.gov/17703734/
[8] Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/

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At Good Peptide I follow published repair research with curiosity and a willingness to revise a verdict, without offering medical advice or a treatment service.